Research conducted by the John A. Burns School of Medicine’s Complementary and Alternative Medicine department has demonstrated that a dietary supplement containing 5-Aminolevulinic acid (5-ALA) has the potential to prevent or delay the progression of diabetes in pre-diabetic populations (Rodriguez et al. 2012). In their study researchers demonstrated a statistically significant decrease in two hours post-oral glucose tolerance test levels in those that took the dietary supplement. The decreases were shown in comparison to participant baseline levels and between the experiment and control groups. Results contribute to knowledge on the benefits of 5-ALA as a safe and potentially effective dietary supplement to help prevent the progression of diabetes.
JABSOM Tech Talk is a collection of blogs to share in depth coverage of science, research and clinical programs happening at JABSOM. The aim is to provide a close-up view of life at the medical school and the impact on the health and well-being of the community.
Since Dr. Ryuzo Yanagimachi (Perry, et al., 1999) created the first transgenic mouse via intracytoplasmic sperm injection (famous fluorescent mice), the John A. Burns School of Medicine continues to blaze the trail in gene technology. Recently, Professor Stefan Mosiyadi, from the Institute for Biogensis Research (IBR), has continued this history of gene innovation by developing a new mouse transgensis technique called transposase-enhanced pronuclear microinjection (te-PNI). This method is significant since it yields a greater successful transgenic mouse percentage than the current methods used today.
This new technique may have a direct impact on the health and quality of life for people suffering from diseases, such as cancer, diabetes, asthma and mental illness. In addition, the use of animal models can also provide insight to therapies for those carrying the genetic potential, but who have not yet manifested disease. There is no doubt that disease may be caused by several factors and gene interactions, however, the use of transgenic animal models in disease research is a significant component in understanding the factors, causes and potential therapies to treat many diseases.